This is a temperature driven recipe for how to cook a brisket in the oven and have it turn out juicy AND tender. This means it’s easy to scale the brisket according to the size/weight you’d like to cook. While you can plan on about 1 hour per pound cook time, this is only a guide. I like to use an oval-shaped Dutch oven (great for roasts) but you can also wrap your brisket tightly in foil and cook it on a baking sheet, too.
Make the dry spice rub. Preheat the oven to 300°F. Set the trimmed brisket in a Dutch oven. In a small bowl, combine the dry ingredients: salt, pepper, smoked paprika, and dry mustard. Mix then rub all over the brisket.
Cook low and slow in the oven. Transfer the Dutch oven (lid on) into the oven. Cook, turning halfway through with tongs for approximately 3 hours (1 hour per pound) or until your thermometer inserted into the thickest part of the brisket reads 175°F. After about 2 ½ hours in the oven, you should see caramelization (brown color) but if you desire more color, you can remove the lid during the last 30 minutes of cooking.
Rest and slice brisket. Allow the brisket to cool for at least 30 minutes. Then move to a cutting board and cut on the bias into 1/4 -inch thick slices. Serve with the cooking juices for dipping.